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    Ttll11 tubulin tyrosine ligase-like family, member 11 [ Mus musculus (house mouse) ]

    Gene ID: 74410, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Ttll11provided by MGI
    Official Full Name
    tubulin tyrosine ligase-like family, member 11provided by MGI
    Primary source
    MGI:MGI:1921660
    See related
    Ensembl:ENSMUSG00000026885 AllianceGenome:MGI:1921660
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D2Ertd624e; 4932702F08Rik; 4933424A20Rik
    Summary
    Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Acts upstream of or within microtubule severing and protein polyglutamylation. Located in ciliary basal body. Is expressed in retina. Orthologous to human TTLL11 (tubulin tyrosine ligase like 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 19.6), cortex adult (RPKM 7.2) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 B; 2 23.9 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (35641250..35870250, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (35751240..35979820, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:35359725-35359878 Neighboring gene STARR-seq mESC enhancer starr_04284 Neighboring gene predicted gene, 35260 Neighboring gene predicted gene, 35202 Neighboring gene STARR-seq mESC enhancer starr_04285 Neighboring gene predicted gene 13446 Neighboring gene STARR-seq mESC enhancer starr_04286 Neighboring gene disabled 2 interacting protein Neighboring gene STARR-seq mESC enhancer starr_04289 Neighboring gene STARR-seq mESC enhancer starr_04292 Neighboring gene RIKEN cDNA 9030204H09 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:35686851-35687121 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:35696893-35697094 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:35697143-35697252 Neighboring gene predicted gene 10829 Neighboring gene predicted gene, 35396 Neighboring gene STARR-positive B cell enhancer ABC_E10098 Neighboring gene STARR-seq mESC enhancer starr_04294 Neighboring gene STARR-seq mESC enhancer starr_04295 Neighboring gene STARR-positive B cell enhancer mm9_chr2:35904821-35905122 Neighboring gene predicted gene, 39798 Neighboring gene NADH:ubiquinone oxidoreductase subunit A8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TTLL1 and TTLL4 polyglutamylases are required for the neurodegenerative phenotypes in pcd mice. Wu HY, et al. PLoS Genet, 2022 Apr. PMID 35404950, Free PMC Article
    2. Tubulin polyglutamylation stimulates spastin-mediated microtubule severing. Lacroix B, et al. J Cell Biol, 2010 Jun 14. PMID 20530212, Free PMC Article
    3. A targeted multienzyme mechanism for selective microtubule polyglutamylation. van Dijk J, et al. Mol Cell, 2007 May 11. PMID 17499049
    4. Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice. Ye B, et al. Nat Commun, 2018 Mar 28. PMID 29593216, Free PMC Article
    5. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Lumayag S, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23341629, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin-glutamic acid ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin-glutamic acid ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule severing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within microtubule severing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyglutamylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein polyglutamylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tubulin polyglutamylase TTLL11
    Names
    polyglutamylase
    tubulin--tyrosine ligase-like protein 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029774.3 → NP_084050.1  tubulin polyglutamylase TTLL11

      See identical proteins and their annotated locations for NP_084050.1

      Status: VALIDATED

      Source sequence(s)
      AL732413, AL773525, AL845477
      Consensus CDS
      CCDS50579.1
      UniProtKB/Swiss-Prot
      A4Q9F4, Q1LZJ9, Q9D4E7
      Related
      ENSMUSP00000028248.5, ENSMUST00000028248.11
      Conserved Domains (1) summary
      cl17255
      Location:178 → 445
      ATP-grasp_4; ATP-grasp domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      35641250..35870250 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162641.1 → XP_036018534.1  tubulin polyglutamylase TTLL11 isoform X1

      Related
      ENSMUSP00000108600.3, ENSMUST00000112976.9
      Conserved Domains (1) summary
      cl17255
      Location:178 → 445
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_028921.2: Suppressed sequence

      Description
      NM_028921.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4Q9F4.1 GenPept UniProtKB/Swiss-Prot:A4Q9F4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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